Osborne bounced back in typical fashion after last week's loss to the Crows.
Rand Walbundrie Walla kept alive its own finals aspirations and put a dent in its opponent Howlong's with a solid win at Howlong.
In one of the Giants' best wins for the season, they started superbly with a six-goal first term and finished with a dominant final term to win by 45 points.
Rhys Dempsey played his best game for the Giants, with live wire Chris Hutchison, Chris Duck and Darcy Kilmartin all providing plenty of drive.
Blake Lieschke was a good target up forward with four goals. Coach Myles Aalbers and Josh Star both booted three goals.
Alex Popko, Caleb Hobbs and Steve Jolliffe were best for the Spiders, who would have been disappointed with the effort after last week's win over Henty.
Osborne bounced back in typical fashion after last weeks loss to the Crows, proving too strong for the in-form Culcairn at Culcairn winning by 48 points.
The Lions at home went into the match a firm favourite but got an old-fashioned football lesson from the hard working and slick Tigers.
After a tight and bruising opening term that had the Lions leading, Osborne took command to kick 12 of the remaining 16 match goals.
Coach Matt Rava kept up his wonderful form to be best afield, while veteran big man Hayden Gleeson kept the dangerous Adam Prior to just two goals.
The talented trio of Jye Shields and the Hallinan boys, Dane and Tim, were best for Culcairn who now trail Osborne in second place by almost five per cent.
Henty has gone into fifth place following its hard working 33 point win over a fellow finals contender Holbrook at Henty. The Swampies despite missing star on-ballers Jared Brennan and Daniel Cox showed they are still a premiership threat with the impressive win.
Damian Cupido cut loose in the final term to finish with six goals, while the excitement machine Kim Kantilla booted four goals.
Holbrook who was in close range all day got within three points during the last quarter before the Swampies finished the stronger to gain the valuable four competition points.
Henty, with midfield dominance, booted six goals to three in an entertaining final term.
Best for Holbrook was Jake Way and Andrew Dear four goals.
Billabong Crows made it eight wins for the season and retains fourth position after it was forced hard to hold off a determined CDHBU at Oaklands.
The Power put up arguably its best performance for the season with Cal Butler, Jordan Wilson, Josh Lewis and Nathan Rhodes outstanding.
The Crows unveiled its latest recruit, with former Brock Burrum Saints forward Nick Brockley making his debut for the club.
Yarrawonga recruit Bronson Schofield was best for the Crows, with John Simpson, Nicholas Morris and Jeremy Bourchier also prominent.
Brock Burrum Saints' inaccuracy at the goal front continued in its 36 point win over Jindera at Jindera in a dour affair in perfect conditions.
The Saints' last six rounds have seen it kick a combined 93-120, for a season total of 165 goals from 360 scoring shots.
They kicked 1-9 in the final term.
The Saints have now strung together 10 straight wins and its only loss being against its next round opponent Culcairn.
Nathan Chammings was again effective up forward for Jindera with four goals, while Matt Crawshaw, Matt Osborne and Michael D'Arcy were also excellent.
Lockhart is back inside the top six after they easily defeated the winless Murray Magpies by 120 points at Urana Road.
The Magpies first quarter was its best for the season with Matt Livingstone, Josh Martin and the consistent Hayden Edwards leading the charge to trail by just seven points.
However, the Demons reacted to a quarter-time blast to boot 18 of the next 19 goals, with Jack Muldoon kicking six.
Jake Phillips and Jordan Harrington both kicked four.
Harrington also notched up over 40 possessions.
Neil Irwin dominated the ruck in his return.
The Hume Football League will have a bye round this weekend.
The next round is scheduled for Saturday, July 20.